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Louie De Palma is a cantankerous, acerbic taxi dispatcher in New York City. He tries to maintain order over a collection of varied and strange characters who drive for him. As he bullies and insults them from the safety of his “cage,” they form a special bond among themselves, becoming friends and supporting each other through the inevitable trials and tribulations of life.

Caitlin "Cat" Sullivan is an NYPD detective working in Brooklyn. After her driving privileges are suspended, she relies on Leo Romba, a highly skilled Brooklyn cab driver from France. Leo becomes Cat's driver and a consultant on her cases. While solving crimes with Leo, Cat is also running her own unauthorized investigation into the death of her father, an NYPD detective thought to have been executed by the Capella crime family. In doing so, she clashes with her boss, Captain Baker, and her ex-husband Gregg, who has picked up the case for the FBI.

While working as a taxi driver on the hectic streets of Tokyo, a reticent walrus gets pulled into a mystery involving a missing teenage girl.

An ordinary taxi driver becomes entangled with a customer that turns out to be a serial killer.