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Based on the bestselling book by Candace Bushnell, Sex and the City tells the story of four best friends, all single and in their late thirties, as they pursue their careers and talk about their sex lives, all while trying to survive the New York social scene. 

The two Warner Brothers Yakko and Wakko and their Warner sister Dot had been (supposedly) created in the 1930's, but their cartoons were too screwy for the general public to handle. The three Warners were locked up in the studio water tower until they escaped in the 90's. There, they run wild, causing chaos everywhere!

Police drama set in New York City, exploring the internal and external struggles of the fictional 15th precinct of Manhattan. Each episode typically intertwined several plots involving an ensemble cast.

Valerie Tyler is a 28-year-old organization freak who loves her 16-year-old sister Holly. Even if Holly is rambunctious. Spontaneous. Impulsive. Disconcerting. And definitely disorganized. Then Holly moves in with Val, and the sisters discover they may make better siblings than roomies.

Mike McNeil is a decorated New York City detective whose toughest assignment is himself. He's struggling to balance a challenging personal life with a job that leaves him wondering on a daily basis if he is the last sane person in New York. His unconventional approach to his job makes him a great cop, even on the most trying days. The only thing he can't figure out is why, if he's the only sane guy around, everyone's always looking at him like he's crazy.

In Tree Hill, North Carolina two half brothers share a last name and nothing else. Brooding, blue-collar Lucas is a talented street-side basketball player, but his skills are appreciated only by his friends at the river court. Popular, affluent Nathan basks in the hero-worship of the town, as the star of his high school team. And both boys are the son of former college ball player Dan Scott whose long ago choice to abandon Lucas and his mother Karen, will haunt him long into his life with wife Deb and their son Nathan.

Downtown is an animated series on MTV on urban life, based on interviews with real people. The show follows a diverse and multiracial cast who live in New York City, and presents their everyday lives through quirky, humorous, and imaginative perspectives from the characters. It was created by Chris Prynoski, a former animator on Beavis and Butt-Head and produced by David McGrath. In 2000, Downtown was nominated for an Emmy in the category of outstanding animated program. Downtown faced a similar fate to many of MTV's other cartoons - it only lasted one season. The use of an original score rather than licensed music makes a sanctioned DVD release unlikely. Some of the show's staff have gone on to work on the action animated series Megas XLR, which uses the same quirky humor found in Downtown as well as the character Goat, reprised by Scott Rienecker.

Hank and Dean Venture, with their father Doctor Venture and faithful bodyguard Brock Samson, go on wild adventures facing megalomaniacs, zombies, and suspicious ninjas, all for the glory of adventure. Or something like that.

Broad City follows two women throughout their daily lives in New York City, making the smallest and mundane events hysterical and disturbing to watch all at the same time.

Follow the investigations of a team of NYPD forensic scientists and police officers identified as "Crime Scene Investigators".

Brothers Brian and Joe Hackett attempt to run an airline on the New England island of Nantucket while surrounded by their various wacky friends and employees.

The series follows the ventures of a Missing Persons Unit of the FBI in New York City.

Savvy Assistant District Attorney Catherine Chandler is saved by a noble, beast-like man named Vincent, who lives in a secret, utopian community beneath New York City. They share a psychic bond, and he protects her from above.

Set in downtown New York in 1900, 'The Knick' is centered on the Knickerbocker Hospital and its staff, notably Dr. John Thackery, the hospital's brilliant chief surgeon who pushes medicine's boundaries, pioneering new procedures despite a severe drug addiction.