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Doctors recount the most memorable cases they’ve ever encountered. Unusual, touching, humorous or life-changing – no story is too big or too small when it comes to the ER.

Telling powerful stories in hourlong episodes, TLC follows medical journeys of morbidly obese people as they attempt to save their own lives. The featured individuals - each weighing more than 600 pounds confront lifelong emotional and physical struggles as they make the courageous decision to undergo high-risk gastric bypass surgery. In addition to drastically changing their appearances, they hope to reclaim their independence, mend relationships with friends and family, and renew their feelings of self-worth.

Dermatologist Sandra Lee, aka Dr. Pimple Popper, helps patients with unique skin conditions reclaim a life free of disguise and embarrassment.