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Virginia Cunningham is confused upon finding herself in a mental hospital, with no memory of her arrival at the institution. Tormented by delusions and unable to even recognize her husband, Robert, she is treated by Dr. Mark Kik, who is determined to get to the root of her mental illness. As her treatment progresses, flashbacks depict events in Virginia's life that may have contributed to her instability.

A wanna-be concert pianist spends his days making a living by collecting debts for his Mafioso father, a lifestyle that could eventually ruin his dreams of a musical career.

Vincent Bruce, a war veteran, begins working as an occupational therapist at Poplar Lodge, a private psychiatric facility for wealthy people where he meets Lilith Arthur, a charming young woman suffering from schizophrenia, whose fragile beauty captivates all who meet her.

Diagnosed with a mental illness halfway through his senior year of high school, a witty, introspective teen struggles to keep it a secret while falling in love with a brilliant classmate who inspires him to open his heart and not be defined by his condition.

Lord Donald and Lady Nancy reside in the magnificent but run-down Longleigh House with James, their mentally disabled adult son. Nancy has fallen seriously ill and Donald is preparing to sell the house to raise enough money to pay for an operation. He arranges for the family nurse, Mary, to take care of Nancy while he leaves to tend to the sale. However, James wants to prove to his father that he can look after his mother on his own and decides to lock Mary out of the house. It isn't long before James starts mixing his mother's pills and forgetting to take his own medication, and as the stress of looking after his mother increases, so too does the severity of his own condition.