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After being resurrected by grave robbers, Larry Talbot searches for Dr. Frankenstein in the hopes of being cured of his lycanthropy. The mad scientist may turn out to be dead, but his monster is just waiting to be found…

Brilliant but arrogant scientist Victor Frankenstein builds a man from spare body parts, only for the monster to come alive and wreak havoc.

Gaira, a humanoid sea beast spawned from the discarded cells of Frankenstein's monster, attacks the shores of Tokyo. While the Japanese military prepares to take action, Gaira's Gargantua brother, Sanda, descends from the mountains to defend his kin. A battle between good and evil ensues, leaving brothers divided and a city in ruins.

During WWII, Germans obtain the immortal heart of Frankenstein's monster and transport it to Japan to prevent it being seized by the Allies. Kept in a Hiroshima laboratory, it is seeming lost when the United States destroys the city with the atomic bomb. Years later a wild boy is discovered wandering the streets of the city alone, born of the immortal heart.

At the turn of the century, all of the Earth's monsters have been rounded up and kept safely on Monsterland. Chaos erupts when a race of she-aliens known as the Kilaaks unleash the monsters across the world.

When Dr. Frankenstein is killed by a monster he created, his daughter and his lab assistant continue his experiments.

Judith Fontaine is looking for her sister Joanie, who has disappeared into the hippie community of Venice, California. It turns out that Joanie has become fallen victim to Groton, an axe-wielding homicidal maniac under the employ of Dr. Durea, the last living descendant of the Frankenstein family and is now both running a house of horrors on the beach's boardwalk and performing experiments on Groton's victims in his basement laboratory.

Within the decadent walls of the Frankenstein mansion, the Baron and his depraved assistant Otto have discovered the means of creating new life. As the Baron's laboratory begins to fill up with stitched body parts, the Baroness dallies with the randy new manservant and soon the decadent, permissive household is consumed by an outrageous, bizarre and hilarious combination of death and dismemberment.

An investigation into a serial killer leads two detectives to discover that Dr. Frankenstein and his creature are still alive after two centuries of genetic experiments.