Splice

Splice

She's not human...not entirely.

R 2010 · 104 min · ★ 5.9 (3K) · Horror, Science Fiction

Elsa and Clive, two rebellious young scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators — only to have that bond turn deadly.

Directed by Vincenzo Natali · Written by Antoinette Terry Bryant

Your Rating

Where to Watch

Rent or Buy

Cast

Adrien Brody Clive Nicoli
Sarah Polley Elsa Kast
Delphine Chanéac Dren
Brandon McGibbon Gavin Nicoli
Simona Măicănescu Joan Chorot
David Hewlett William Barlow
Abigail Chu Child Dren
Doug Hicton Lab tech (uncredited)

Trailers & Videos

Make it a double feature

3h 32m together

Splice

Ginger Snaps

Both from Vincenzo Natali.

More from Vincenzo NataliSee all →

VisionQuest

VisionQuest · 2026

SeriesSci-Fi & FantasyDrama

With a bounty on his head, Vision must confront his nature and resist Ultron's influence to survive.

Hannibal

Hannibal · 2013

SeriesDramaCrime

Both a gift and a curse, Graham has the extraordinary ability to think like his prey—he sees what they see, feels what they feel. But while Graham is pursuing an especially troubling, cannibalistic murderer, Special Agent Jack Crawford teams him with a highly respected psychiatrist – a man with a taste for the criminal minded – Dr. Hannibal Lecter.

Westworld

Westworld · 2016

SeriesSci-Fi & FantasyWestern

A dark odyssey about the dawn of artificial consciousness and the evolution of sin. Set at the intersection of the near future and the reimagined past, it explores a world in which every human appetite, no matter how noble or depraved, can be indulged.

Orphan Black

Orphan Black · 2013

SeriesDramaSci-Fi & Fantasy

A streetwise hustler is pulled into a compelling conspiracy after witnessing the suicide of a girl who looks just like her.

Locke & Key

Locke & Key · 2020

SeriesSci-Fi & FantasyDrama

After their dad's murder, three siblings move with their mom to his ancestral estate, where they discover magical keys that unlock powers — and secrets.

The Peripheral

The Peripheral · 2022

SeriesSci-Fi & FantasyDrama

Stuck in a small Appalachian town, a young woman’s only escape from the daily grind is playing advanced video games. She is such a good player that a company sends her a new video game system to test…but it has a surprise in store. It unlocks all of her dreams of finding a purpose, romance, and glamour in what seems like a game…but it also puts her and her family in real danger.

The Strain

The Strain · 2014

SeriesSci-Fi & FantasyDrama

A high concept thriller that tells the story of Dr. Ephraim Goodweather, the head of the Center for Disease Control Canary Team in New York City. He and his team are called upon to investigate a mysterious viral outbreak with hallmarks of an ancient and evil strain of vampirism. As the strain spreads, Eph, his team, and an assembly of everyday New Yorkers, wage war for the fate of humanity itself.

Lost in Space

Lost in Space · 2018

SeriesSci-Fi & FantasyAction & Adventure

After crash-landing on an alien planet, the Robinson family fights against all odds to survive and escape. But they're surrounded by hidden dangers.

Guillermo del Toro's Cabinet of Curiosities

Guillermo del Toro's Cabinet of Curiosities · 2022

Guillermo del Toro's Cabinet of Curiosities

SeriesDramaMystery

Bizarre nightmares unfold in eight tales of terror in this visually stunning, spine-tingling horror collection curated by Guillermo del Toro.

Getting Gilliam

Getting Gilliam · 2005

Getting Gilliam

MovieDocumentary

This documentary follows director Terry Gilliam through the process of making his film Tideland.

Tremors

Tremors · 2018

SeriesComedySci-Fi & Fantasy

25 years after the movie, the prehistoric subterranean monsters known as Graboids return to Perfection, Nevada.

Hemlock Grove

Hemlock Grove · 2013

SeriesMysteryDrama

One cannot quench his all-consuming thirst. The other cannot tame the beast clawing its way out. In the sleepy Pennsylvania village of Hemlock Grove, two young men struggle to accept painful truths: about family, themselves, the mystery of the White Tower - and a terrifying new threat so powerful it will turn them from predators into prey.

Space Cases

Space Cases · 1996

SeriesDramaSci-Fi & Fantasy

Space Cases is a science fiction television series. Its premise revolves around a group of misfit students and two adults who are stranded far from home aboard an alien ship. Their attempts at journeying back see many dangerous adventures and controversies, with some occasionally more mature themes.

American Gods

American Gods · 2017

SeriesDramaMystery

An ex-con becomes the traveling partner of a conman who turns out to be one of the older gods trying to recruit troops to battle the upstart deities. Based on Neil Gaiman's fantasy novel.

Ginger Snaps

Ginger Snaps · 2000

MovieHorrorFantasy

The story of two outcast sisters, Ginger and Brigitte, in the mindless suburban town of Bailey Downs. On the night of Ginger's first period, she is savagely attacked by a wild creature. Ginger's wounds miraculously heal but something is not quite right. Now Brigitte must save her sister and save herself.

Marvel's Luke Cage

Marvel's Luke Cage · 2016

Marvel's Luke Cage

SeriesDramaAction & Adventure

Given superstrength and durability by a sabotaged experiment, a wrongly accused man escapes prison to become a superhero for hire.

More Like This

Strange Days

Strange Days · 1995

MovieCrimeScience Fiction

In the last days of 1999, ex-cop turned street hustler Lenny Nero receives a disc which contains the memories of the murder of a prostitute. With the help of bodyguard Mace, he starts to investigate and is pulled deeper and deeper in a whirl of murder, blackmail and intrigue.

A Nightmare on Elm Street

A Nightmare on Elm Street · 1984

A Nightmare on Elm Street

Teenagers in a small town are dropping like flies, apparently in the grip of mass hysteria causing their suicides. A cop's daughter, Nancy Thompson, traces the cause to child molester Fred Krueger, who was burned alive by angry parents many years before. Krueger has now come back in the dreams of his killers' children, claiming their lives as his revenge. Nancy and her boyfriend, Glen, must devise a plan to lure the monster out of the realm of nightmares and into the real world...

Contact

Contact · 1997

MovieDramaScience Fiction

A radio astronomer receives the first extraterrestrial radio signal ever picked up on Earth. As the world powers scramble to decipher the message and decide upon a course of action, she must make some difficult decisions between her beliefs, the truth, and reality.

Gattaca

Gattaca · 1997

MovieScience FictionDrama

Vincent is an all-too-human man who dares to defy a system obsessed with genetic perfection. He is an "In-Valid" who assumes the identity of a member of the genetic elite to pursue his goal of traveling into space with the Gattaca Aerospace Corporation.

Army of Darkness

Army of Darkness · 1992

Army of Darkness

MovieFantasyHorror

Ash, a handsome, shotgun-toting, chainsaw-armed department store clerk, is time warped backwards into England's Dark Ages, where he romances a beauty and faces legions of the undead.

This Island Earth

This Island Earth · 1955

This Island Earth

MovieScience FictionAdventure

Aliens have landed and are hiding on Earth, but need Earth’s scientists to help them fight an inter-planetary war.

Videodrome

Videodrome · 1983

MovieHorrorScience Fiction

As the president of a trashy TV channel, Max Renn is desperate for new programming to attract viewers. When he happens upon "Videodrome," a TV show dedicated to gratuitous torture and punishment, Max sees a potential hit and broadcasts the show on his channel. However, after his girlfriend auditions for the show and never returns, Max investigates the truth behind Videodrome and discovers that the graphic violence may not be as fake as he thought.

Fantastic Four: Rise of the Silver Surfer

Fantastic Four: Rise of the Silver Surfer · 2007

Fantastic Four: Rise of the Silver Surfer

MovieScience FictionAdventure

The Fantastic Four return to the big screen as a new and all powerful enemy threatens the Earth. The seemingly unstoppable 'Silver Surfer', but all is not what it seems and there are old and new enemies that pose a greater threat than the intrepid superheroes realize.

Hulk

MovieScience FictionAdventure

Bruce Banner, a genetics researcher with a tragic past, suffers massive radiation exposure in his laboratory that causes him to transform into a raging green monster when he gets angry.

The Amazing Spider-Man

The Amazing Spider-Man · 2012

The Amazing Spider-Man

MovieActionAdventure

A teenage Peter Parker grapples with both high school and amazing super-human crises as his alter-ego Spider-Man.

Calvaire

Calvaire · 2005

A few days before Christmas, traveling entertainer Marc Stevens is stuck at nightfall in a remote wood in the swampy Hautes Fagnes region of Liège when his van breaks down. An odd chap who's looking for a lost dog then leads Marc to a shuttered inn.

My Stepmother Is an Alien

My Stepmother Is an Alien · 1988

My Stepmother Is an Alien

MovieComedyScience Fiction

Trying to rescue her home planet from destruction, a gorgeous extraterrestrial named Celeste arrives on Earth and begins her scientific research. She woos quirky scientist Dr. Steve Mills, a widower with a young daughter. Before long, Celeste finds herself in love with Steve and her new life on Earth, where she experiences true intimacy for the first time. But when she loses sight of her mission, she begins to question where she belongs.

The Hills Have Eyes

The Hills Have Eyes · 1977

The Hills Have Eyes

Taking an ill-advised detour en-route to California, the Carter family soon run into trouble when their RV breaks down in the middle of the desert. Stranded, they find themselves at the mercy of monstrous cannibals lurking in the surrounding hills.

The Island of Dr. Moreau

The Island of Dr. Moreau · 1996

The Island of Dr. Moreau

MovieScience FictionHorror

After surviving a plane crash caused by a magnetic storm, United Nations attorney Edward Douglas stumbles upon a mysterious island and is shocked to discover that a brilliant scientist and his lab assistant have found a way to combine human and animal DNA—with horrific results.

The Avengers

The Avengers · 1998

MovieActionAdventure

British Ministry agent John Steed, under direction from "Mother", investigates a diabolical plot by arch-villain Sir August de Wynter to rule the world with his weather control machine. Steed investigates the beautiful Doctor Mrs. Emma Peel, the only suspect, but simultaneously falls for her and joins forces with her to combat Sir August.

The Core

The Core · 2003

MovieScience FictionAdventure

Geophysicist Dr. Josh Keyes discovers that an unknown force has caused the earth's inner core to stop rotating. With the planet's magnetic field rapidly deteriorating, our atmosphere literally starts to come apart at the seams with catastrophic consequences. To resolve the crisis, Keyes, along with a team of the world's most gifted scientists, travel into the earth's core. Their mission: detonate a device that will reactivate the core.

Rate this film

Your ratings make Midnight smarter