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Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.

A man struggles with memories of his past, including a wife he cannot remember, in a nightmarish world with no sun and run by beings with telekinetic powers who seek the souls of humans.

A man becomes involved in a memory manipulation operation to try and regain lost memories. He thinks the exercise may help repair his failed marriage, but accidentally ends up with the mind of a serial killer.

The only son of wealthy widow Violet Venable dies while on vacation with his cousin Catherine. What the girl saw was so horrible that she went insane; now Mrs. Venable wants Catherine lobotomized to cover up the truth.

After returning home from the Vietnam War, veteran Jacob Singer struggles to maintain his sanity. Plagued by hallucinations and flashbacks, Singer rapidly falls apart as the world and people around him morph and twist into disturbing images. His girlfriend, Jezzie, and ex-wife, Sarah, try to help, but to little avail. Even Singer's chiropractor friend, Louis, fails to reach him as he descends into madness.

When Simon awakens in the hospital after surviving a near-fatal accident, amnesia has erased the last two years from his memory. He learns that his brother was killed, he has married a woman he doesn't remember and he's haunted by strange visions of the woman he loved.

A man awakens in a car wreck at the bottom of a steep cliff. He can't remember who he is or how he got there, but a report over the radio fills in some of the blanks, as it describes a violent bank robbery and names a perpetrator who happens to be sitting dead in the back seat.