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When a hapless, unfunny, wanna-be comedian picks up a mysterious hitchhiker on his way to Vegas to audition for the Monte Guy show, he unwittingly becomes trapped in a desert-town killing spree that also has a very unexpected consequence - it improves his comedy.

In the summer of 1859, a widowed physician reluctantly agrees to take a recently freed slave and her mysterious Caucasian daughter on a five-day journey through the bloody West to find a distant town's Faith Healer. The woman believes her daughter is possessed. The doctor believes she simply carries The Sickness. Either way the fact remains that every living thing the girl touches mysteriously dies.