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Irena Sendler is a Catholic social worker who has sympathized with the Jews since her childhood, when her physician father died of typhus contracted while treating poor Jewish patients. When she initially proposes saving Jewish children from the Warsaw Ghetto, her idea is met with skepticism by fellow workers, her parish priest, and even her own mother Janina.

Johnny is a long-serving MI5 officer. His boss dies suddenly, leaving behind an inexplicable file which threatens the stability of the organisation.