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William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.

When a group of PHD students travel to Mexico in search of a lost Aztec temple, they discover a terrible secret that could kill them.

A professional cellist has an encounter with a stranger on the subway which has unexpected and far-reaching ramifications on his life.