Ivan

Mercer's brother, an amateur pilot, crashes on an island and is killed by a giant spider. A year later, when Mercer goes in search of him, she discovers a breed of venomous arachnids ready to attack.

Set 15 years after "Twentieth Century Boys," Kanna (Airi Taira) reunites with several main characters from the first film in an attempt to stop Friend's increasing influence over the world and continued plans to eliminate humanity, as detailed in the New Book of Prophecy.