William Cavanaugh

Montana cattleman Austin Brandt is jilted by Rosemary, who elopes with stranger Royce Greer, but he is consoled by his twenty-year-old niece Joan. Rosemary later returns to Custer City to run a dance hall with her husband, who mistreats her.

Annette is in love with Sheriff André Porel, but her father Gaston, promises her to Paul Gerard, after Gerard witnesses Gaston kill Indian Charlie. Despondent, Annette considers suicide, but Gerard drinks the poison by mistake. Annette is convicted of murder and is being led to her execution by André when an avalanche buries the gallows and Gaston. The villagers take this as a sign of Annette's innocence; she is released and marries André.

In the Canadian province of Acadia, young Evangeline is betrothed to Gabriel. But before their wedding can take place, the British imprison the men and send them into exile with their lands forfeit to the Crown Evangeline follows the exiled men in hopes of finding her beloved, but even after he and the other Acadians are released in Louisiana, she cannot find him, always arriving at some locale just after he has departed. But she dedicates her life to searching the continent for the man she loves.

Dr. Robert Winston loses faith in himself and his religion when his own mother dies under his scalpel. Abandoning his profession, he moves to the Canadian Northwest, where he avoids companionship and drinks constantly. Despite Robert's atheism, he attracts the interest of Jeanette Mercier, the minister's daughter, and under her gentle influence, he is slowly regenerated. In the meantime, an Indian named Lone Deer bids a temporary farewell to his sweetheart Winona, whose father wishes to die among his own people, but when he finds her canoe overturned in the water, he assumes that she has drowned. Later Lone Deer saves Jeanette from Lou Baribeau, the brutal and lecherous company agent, but is seriously wounded in the struggle. Rev. Mercier convinces Robert to operate, and because the procedure proves successful, the doctor regains his faith and marries Jeanette. Winona finally returns to aid in Lone Deer's recovery.

In attempting to develop a chemical which would make a person super-intelligent, Dr. Montrose fails and the subjects of his experiments metamorphose into hideous monsters who band together and prey on humans. With the police stymied, a young detective attempts to track down the leader of the group of killers, known only to have a small crimson stain in one eye.

The Great Gamble is a 1919 movie serial.