J. Stuart Blackton Jr.

An ex-vaudeville actor is working as the assistant to a doctor who has Frankenstein aspirations. The ex-vaudeville actor kills the doctor and decides to assume the identity of the dead physician.

Eugene Solari is fanatically jealous of his beautiful wife Enid. While on a mission for her father, she visits Major Trevor. Her husband finds out and, enraged, rushes to Trevor's house. Enid tries to beat him there to warn Trevor, but is too late--when she gets there Eugene shoots her and then kills himself, but not before he names Trevor as his killer. Trevor is arrested for his murder.

Prospector Harry Farley returns from Alaska to find that his sister, Helen, has gone to New York with Florence, her blind daughter, after being deserted by her husband, Richard Norman. Under the name of Sidney Heaton, Norman has married Blanche Maberly and fallen in with a bootlegging gang while succumbing to the blackmail of Dick Watkins. Helen dies, Heaton kidnaps Florence, but Harry tracks him to the Adirondacks.

A once-promising doctor begins a downward spiral, finding himself in opium dens, a carnival freak show, and drugs parties.

A young female boarding house tenant becomes an unwanted object of male attention.