George 'Red' Callender

In Prohibition-era Chicago, musicians Joe and Jerry witness a mob hit, and flee the state in an all-female band disguised as Josephine and Daphne, but further complications set in.

Ex-convict Eddie and his wife, Kristine, attempt to build a new life for themselves and their daughter Kathy in San Francisco, but police officer Mike Vido is determined to send Eddie back to prison.

Will Handy grows up in Memphis with his preacher father and his Aunt Hagar. His father intends for him to use his musical gifts only in church, but he can't stay away from the music of the streets and workers. After he writes a theme song for a local politician, Gogo, a speakeasy singer, convinces Will to be her accompanist. Will is estranged from his father for many years while he writes and publishes many blues songs. At last the family is reunited when Gogo brings them to New York to see Will's music played by a symphony orchestra.